Figure 4.

Example parameter maps calculated from MRI data. Both patients received vandetanib 300 mg and had RECIST-defined progressive disease on day 57 (patient 1983, Panel a) and day 62 (patient 2999, Panel b). Only the cutout of the lesion is shown. Definitions: K^trans volume transfer constant between blood plasma and extravascular extracellular space V_e, extravascular extracellular volume fraction; Unfit image pixels, which could not be fitted by DCE-MRI models (low uptake of contrast agent); iAUC₆₀ initial area under the DCE-MRI contrast agent concentration--time curve after 60 s; R10 native longitudinal relaxation rate constant before contrast agent administration;T2* effective transverse relaxation time.