Figure 2.

Force curves (restoring force in pN versus tip-substrate separation in nm) containing characteristic pattern of fibrin ‘A-a’ knob-hole forced dissociation. Four types of characteristic patterns were identified: doublet (A), doublet with preceding event (B), doublet with following event (C), and doublet with both preceding and following events (D). Event numbers are indicated. Linear approximation of slope before one event, as used for loading rate calculation, is shown as dashed gray line (the line is slightly offset for clarity).