Table 2.
Latency to Seizure with MPEP
| Mouse | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Recovery Time (min) | Time of Death (sec) | % Mice Dead |
|---|---|---|---|---|---|---|---|---|
| WT Female | 168 ± 25 | 842 ± 210 | NA | NA | NA | 39 ± 4.04 | NA | 0 |
| n = 3 | n = 7 | n = 0 | n = 0 | n = 0 | n = 9 | n = 0 | ||
| WTMale | 140 ± 27 | 801±151 | 522 ± 56 | 465 | NA | 39 ± 2.54 | NA | 0 |
| n = 10 | n = 9 | n = 2 | n = 1 | n = 0 | n = 10 | n = 0 | ||
| KO Female | 90 ± 10 | 290 ± 68 | 387 ± 75 | 462 | NA | 43 ± 3.48 | NA | 0* |
| n = 6 | n = 5 | n = 2 | n = 1 | n = 0 | n = 6 | n = 0 | ||
| KO Male | 146 ± 13 | 393 ± 92 | 325 ± 80 | 244 | NA | 31 ± 3.47 | NA | 0 |
| n = 6 | n = 6 | n = 2 | n = 1 | n = 0 | n = 8 | n = 0 | ||
| Tg2576 Female | 149 ± 33 | 198 ± 16 | 368 ± 44 | 595 ±182 | 792 ± 179 | 60 | 1017 ± 5 | 50** |
| n = 2 | n = 4 | n = 3 | n = 3 | n = 3 | n = 1 | n = 2 | ||
| Tg2576 Male | 121 ± 19 | 216 ± 41 | 344 ±101 | 370 ± 114 | 576 ± 191 | 39 ± 11.00 | 725 ±161 | 75 |
| n = 3 | n = 8 | n = 8 | n = 7 | n = 6 | n = 2 | n = 6 | ||
| FRAXAD Female | 155 ±3 | 207 ± 25 | 322 ± 57 | 328 ± 55 | 223 ± 39 | 46 ± 5.05 | 267 ± 46 | 40 |
| n = 2 | n = 5 | n = 5 | n = 5 | n = 2 | n = 3 | n = 2 | ||
| FRAXAD Male | ND | 261 ±172 | 253 ± 33 | 220 ± 57 | 232 ± 56 | 52 ±0 | 340 ±139 | 60 |
| n = 5 | n = 3 | n = 3 | n = 3 | n = 3 | n = 2 | n = 3 |
*
2 Fmr-1 KO female mice died from MPEP alone (no PTZ injection) and were not included.
**
1 Tg2576 female mouse died from MPEP alone (no PTZ injection) and was not included. Of the 5 mice in the Tg2576 female group, 1 mouse had a stage 5 seizure and recovered within 1 hr, 1 mouse had a stage 2 seziure and did not recover within 1 hr, 2 mice died and 1 mouse died from MPEP alone.