Table 3.
PTZ-Induced Seizure Endpoint Distribution
| MPEP | yes | yes | yes | yes | yes | yes | yes | yes | no* | no* | no* | no* |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| gender | male | female | male | female | male | female | male | female | male | female | male | female |
| strain | WT | WT | fmr-1 KO | fmr-1 KO | Tg2576 | Tg2576 | FRAXAD | FRAXAD | Tg2576 | Tg2576 | FRAXAD | FRAXAD |
| n | 10 | 9 | 8 | 6 | 8 | 4 | 5 | 5 | 7 | 6 | 12 | 7 |
| grade 1 endpt | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| grade 2 endpt | 7 | 7 | 6 | 3 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 0 |
| grade 3 endpt | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
| grade 4 endpt | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 1 | 0 | 5 | 1 |
| grade 5 endpt | 0 | 0 | 0 | 0 | 6 | 3 | 3 | 2 | 5 | 5 | 5 | 6 |
| multiple grade 3 | 1 | 0 | 1 | 0 | 3 | 2 | 0 | 0 | ||||
| multiple grade 4 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 0 | ||||
| multiple grade 5 | 0 | 0 | 0 | 0 | 2** | 0 | 0 | 0 |
*
Please refer to reference [10].
**
Grade 5 seizures involve hyperactive bouncing followed by tonic-clonic seizures and death. These mice were scored as multiple grade 5 seizures due to two rounds of hyperactive bouncing and tonic-clonic seizures. The mice recovered from the first round and later entered a second round resulting in death.