Table 1.
Classification of major neurodegenerative disorders
| Disorder | Anatomy | Major clinical feature | |
|---|---|---|---|
| Amyloidoses | |||
| Aβ | Alzheimer disease | Corticolimbic | Dementia |
| ABri | Familial British dementia | Corticolimbic & cerebellar | Dementia & ataxia |
| PrP | Creutzfeldt-Jakob disease | Cortical & basal ganglia | Dementia & movement disorder |
| Gerstmann-Straussler-Scheinker | Cortical & Cerebellar | Ataxia & dementia | |
| Tauopathies | |||
| 4R | Progressive supranuclear palsy | Basal ganglia & brainstem | Parkinsonism |
| Corticobasal degeneration | Cortical & basal ganglia | Focal cortical syndrome & parkinsonism | |
| Argyrophilic grain disease | Limbic | Amnestic cognitive impairment | |
| 3R | Pick's disease | Corticolimbic | Dementia & focal cortical syndromes |
| 3R+4R | Tangle predominant dementia | Limbic | Dementia |
| Guam Parkinson dementia complex | Cortex & brainstem | Dementia & parkinsonism | |
| Synucleinopathies | |||
| Parkinson disease | Brainstem | Parkinsonism | |
| Dementia with Lewy bodies | Corticolimbic & brainstem | Dementia & parkinsonism | |
| Multiple system atrophy | Basal ganglia, brainstem & cerebellum | Parkinsonism & ataxia | |
| TDP-43 proteinopathies | |||
| Amyotrophic lateral sclerosis | Motor neurons | Spasticity & weakness | |
| Frontotemporal lobar degeneration with ubiquitinated inclusions | Cortex & basal ganglia | Dementia & focal cortical syndromes |