Figure 6.

Triptolide attenuates LPS-induced cytokine production in vivo in a dose-dependent manner. C57BL6 mice (5–6 weeks old) were given the indicated doses of triptolide, or equal volumes of vehicle i.p, and then challenged with LPS (5 mg/kg body weight). Cytokine concentrations in the serum were determined by ELISA. (A) Effects of triptolide on TNF-α biosynthesis in vivo. (B) Effects of triptolide on IL-6 production in vivo. Values represent the mean ± S.E. from 8–12 animals. †, p < 0.05, compared to control group (not stimulated with LPS). *, p<0.05, compared to the group received vehicle and then stimulated with LPS.