Figure 4.

Nuclear EGFR expression contributes to cisplatin resistance. A. cell proliferation of MCF7-EGFR expressing cells. MCF7-EGFR expressing cells were seeded in the 96 well plates and cell proliferation was measured with MTT assay. Two independent cell lines from different constructs show similar growth rate although only one is shown in the graph in the plot. B. cell survival of MCF7-EGFR expressing cells in response to cisplatin (CDDP) treatment. MCF-EGFR expressing cells were seeded in 96 well plates over night and treated with 25 uM cisplatin for an additional 48 hours. Cell survival was measured by MTT assay.