Table 1.
Genome-Wide Association Studies of CAD and MI (p<5 × 10−5)
| Phenotype | Chromo-somal Region | Reported Gene(s) | SNP | Risk Allele Frequency | P-value | Odds ratio | 95% CI | Reference |
|---|---|---|---|---|---|---|---|---|
| CAD | 1p13.3 | CELSR2-PSRC1-SORT1 | rs5999839 | 0.23 | 4 × 10−19 | 1.29 | 1.18–1.40 | [18] |
| early-onset MI | 1p13 | CELSR2-PSRC1-SORT1 | rs646776 | 0.81 | 1.5 × 10−8 | 1.17 | 1.11–1.24 | [21] |
| early-onset MI | 1p32 | PCSK9 | rs11206510 | 0.81 | 9.6 × 10−9 | 1.15 | 1.10–1.21 | [21] |
| early-onset MI | 1q41 | MIA3 | rs1746048 | 0.72 | 5.9 × 10−7 | 1.13 | 1.08–1.18 | [21] |
| CAD | 1q41 | MIA3 | rs17465637 | 0.29 | 1 × 10−6 | 1.2 | 1.12–1.30 | [18] |
| CAD | 1q43 | NA | rs17672135 | 0.87 | 2 × 10−6 | 1.43 | 1.23–1.64 | [16] |
| early-onset MI | 2q33 | WDR12 | rs6725887 | 0.14 | 1.3 × 10−8 | 1.17 | 1.11–1.23 | [21] |
| CAD | 2q36.3 | pseudogene | rs2943634 | 0.65 | 2 × 10−7 | 1.21 | 1.13–1.30 | [18] |
| CAD | 3q22.3 | MRAS | rs9818870 | NA | 7.4 × 10−13 | 1.15 | 1.11–1.19 | [92] |
| CAD | 5q21 | NA | rs383830 | 0.22 | 1 × 10−5 | 1.60 | 1.16–2.21 | [16] |
| early-onset MI | 6p24 | PHACTR1 | rs12526453 | 0.65 | 1.3 × 10−9 | 1.12 | 1.08–1.27 | [21] |
| CAD | 6q25 | MTHFD1L | rs6922269 | 0.25 | 2 × 10−5 | 1.17 | 1.04–1.32 | [16] |
| CAD | 6q25.1 | MTHFD1L | rs6922269 | 0.25 | 3 × 10−8 | 1.23 | 1.15–1.33 | [18] |
| CAD | 6q27 | SCL22A3-LPAL2-LPA | rs2048327, rs3127599, rs7767084, rs10755578 (CTTG and CCTC haplotype) | NA | 1.2 × 10−9 (CTTG), 4.2 × 10−15 (CCTC) | 1.20 (CTTG) 1.82 (CCTC) | 1.13–1.28 (CTTG) 1.57–2.12 (CCTC) | [86]* |
| early-onset MI | 9p21 | CDKN2A, CDKN2B | rs4977574 | 0.56 | 1.1 × 10−30 | 1.28 | 1.23–1.33 | [21] |
| MI | 9p21.3 | CDKN2A, CDKN2B | rs10757278 | 0.45 | 1 × 10−20 | 1.28 | 1.22–1.35 | [19] |
| CAD | 9p21.3 | intergenic | rs1333049 | 0.47 | 3 × 10−19 | 1.36 | 1.27 – 1.46 | [18] |
| CAD | 9p21.3 | CDKN2A, CDKN2B | rs1333049 | 0.47 | 1 × 10−13 | 1.47 | 1.27–1.70 | [16] |
| CAD | 9p21.3 | NA | rs10757274 and rs2383206 | NA | NA | NA | NA | [17] |
| CAD | 10q11.21 | CXCL12 | rs501120 | 0.13 | 9 × 10−8 | 1.33 | 1.20–1.48 | [18] |
| early-onset MI | 10q11 | CXCL12 | rs1746048 | 0.84 | 3.4 × 10−5 | 1.14 | 1.08–1.21 | [21] |
| MI | 12q24 | SH2B3 | rs3184504 | 0.38 | 8.6 × 10−8 | 1.13 | 1.08–1.18 | [82] |
| CAD | 12q24.41 | HNF1A-C12orf43 | rs2259816 | NA | 5 × 10−7 | 1.08 | 1.05–1.11 | [92] |
| CAD | 15q22.33 | SMAD3 | rs17228212 | 0.30 | 2 × 10−7 | 1.21 | 1.13–1.30 | [18] |
| CAD | 16q23 | NA | rs8055236 | 0.20 | 6 × 10−6 | 1.91 | 1.33–2.74 | [16] |
| early-onset MI | 19p13 | LDLR | rs1122608 | 0.75 | 1.9 × 10−9 | 1.15 | 1.10–1.20 | [21] |
| CAD | 19q12 | NA | rs7250581 | 0.22 | 3 × 10−5 | 1.06 | 0.79–1.43 | [16] |
| early-onset MI | 21q22 | SLC5A3-MRPS6-KCNE2 | rs9982601 | 0.13 | 6.4 × 10−11 | 1.20 | 1.14–1.27 | [21] |
| CAD | 22q12 | NA | rs688034 | 0.31 | 4 × 10−6 | 1.11 | 0.99–1.25 | [16] |
NA = not available
*
Genome-wide haplotype analysis