Table 1. Comparison of genotype frequencies of methyltetrahydrofolate reductase C677T polymorphism with primary open angle glaucoma, primary closed angle glaucoma and controls.
| Collective Subjects | |||||||
|---|---|---|---|---|---|---|---|
|
Genotype |
Controls (143) |
POAG (173) |
OR (95%CI) |
p (χ2) |
PCAG (122) |
OR (95%CI) |
p (χ2) |
| CC |
101 (71%) |
123 (71%) |
0.98 (0.60-1.59) |
0.98 (0.02) |
84 (69%) |
1.09 (0.64-1.84) |
0.001 (12.6) |
| CT |
41 (29%) |
49 (28%) |
1.02 (0.62-1.66) |
|
26 (21%) |
1.02 (0.62-1.66) |
|
| TT |
1 (1%) |
1 (1%) |
1.21 (0.12-11.7) |
|
12 (10%) |
0.06 (0.01-0.39) |
|
|
Subjects of Pathan Ethnicity | |||||||
|
Genotype |
Control (70) |
POAG (96) |
OR (95%CI) |
p (χ2) |
PCAG (61) |
OR (95%CI) |
p (χ2) |
| CC |
53 (76%) |
70 (73%) |
1.16 (0.57-2.33) |
0.43 (1.7) |
38 (62%) |
1.89 (0.89-3.98) |
0.14 (3.9) |
| CT |
16 (23%) |
26 (27%) |
0.79(0.39-1.62) |
|
19 (31%) |
0.65 (0.30-1.41) |
|
| TT |
1 (1%) |
0 |
- |
|
4 (7%) |
0.21 (0.03-1.43) |
|
|
Subjects of Punjabi Ethnicity | |||||||
|
Genotype |
Control (73) |
POAG (77) |
OR (95%CI) |
p (χ2) |
PCAG (61) |
OR (95%CI) |
p (χ2) |
| CC |
48(66%) |
53 (69%) |
0.87 (0.44-1.71) |
0.54 (1.2) |
46 (75%) |
0.63 (0.29-1.33) |
<0.001 (17.2) |
| CT |
25(34%) |
23 (30%) |
1.22 (0.62-2.42) |
|
7 (11%) |
4.02 (1.62-9.89) |
|
| TT | 0 | 1 (1%) | 0.00 (0.00-4.070 | 8 (13%) | 0.00 (0.00-0.36) | ||