Table 2. Comparison of genotype frequencies of methyltetrahydrofolate reductase A1298C polymorphism with primary open angle glaucoma, primary closed angle glaucoma and controls.
| Collective Subjects | |||||||
|---|---|---|---|---|---|---|---|
|
Genotype |
Controls (143) |
POAG(173) |
OR (95%CI) |
p (χ2) |
PCAG (122) |
OR (95%CI) |
p (χ2) |
| AA |
20 (14%) |
35 (20%) |
0.64 (0.35-1.16) |
0.25 (2.7) |
34 (28%) |
0.42 (0.23-0.78) |
0.007 (9.7) |
| AC |
97 (68%) |
114 (66%) |
1.09 (0.68-1.74) |
|
76 (62%) |
1.28 (0.77-2.12) |
|
| CC |
26 (18%) |
24 (14%) |
1.38 (0.76-2.51) |
|
12 (10%) |
2.04 (0.99-4.18) |
|
|
Subjects of Pathan Ethnicity | |||||||
|
Genotype |
Control (70) |
POAG (96) |
OR (95%CI) |
p (χ2) |
PCAG (61) |
OR (95%CI) |
p (χ2) |
| AA |
17 (24%) |
29 (30%) |
0.74 (0.37-1.48) |
0.19 (3.3) |
8 (13%) |
2.12 (0.86-5.23) |
0.26 (2.7) |
| AC |
44 (63%) |
62 (65%) |
0.93 (0.49-1.75) |
|
43 (71%) |
0.71 (0.34-1.47) |
|
| CC |
9 (13%) |
5 (5%) |
2.68 (0.89-8.01) |
|
10 (16%) |
0.75 (0.29-1.95) |
|
|
Subjects of Punjabi Ethnicity | |||||||
|
Genotype |
Control (73) |
POAG (77) |
OR (95%CI) |
p (χ2) |
PCAG (61) |
OR (95%CI) |
p (χ2) |
| AA |
3 (4%) |
6 (8%) |
0.51 (0.13-1.94) |
0.60 (1.01) |
26 (43%) |
0.06 (0.02-0.19) |
<0.001(33.9) |
| AC |
53 (73%) |
52 (68%) |
1.28 (0.63-2.55) |
|
33 (54%) |
2.25 (1.10-4.59) |
|
| CC | 17 (23%) | 19 (25%) | 0.93 (0.44-1.95) | 2 (3%) | 8.95 (2.18-36.21) | ||