Table 1. Summary of clinical parameters of AML patients used in this study.
Patient ID | FAB | % CD34 | Karyotype | FLT3-ITD | Responses to cytokines |
2003-119 | M0 | 80 | N | + | c.a. TPO, IL-3, GM-CSF |
2005-258 | M0 | 73 | -5q; +6 | ND | G-CSF, IL-3 |
2006-014 | M1 | 19 | N | + | TPO, IL-3 GM-CSF |
2005-016 | M1 | 65 | N | − | c.a., G-CSF |
2004-168 | M2 | 21 | del (9) (q12;q22) | + | c.a., TPO, IL-3 |
2007-046 | M2 | 20 | N | + | TPO, G-CSF, IL-3 |
2003-152 | M4 | 72 | Inv (16) | − | TPO, G-CSF, IL-3 |
2005-289 | M5 | 95 | N | − | IL-3, GM-CSF, G-CSF |
2003-114 | M5 | 27 | t(11;20) | + | c.a., G-CSF, GM-CSF |
2007-272 | M7 | 36 | Complex | − | c.a. TPO, IL-3 |
AML cells derived from peripheral blood (PB); Percentage of CD34+ (% CD34) in the total AML mononuclear cell fraction; FAB, French-American-British classifications; FLT3-ITD (internal tandem duplication) was present (+) or absent (−) in the AML cells; ND, not determined; N, normal; c.a. constitutive activation of STAT5.