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. 2009 Oct 27;11(22):5178–5180. doi: 10.1021/ol902079g

Table 1. Cu(II)-Mediated Oxidative Coupling of 1 with N-Nucleophilesa.

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a

Reaction conditions for 2a−2g. Condition A: 1 (0.3 mmol), 2 (1.5 mmol), pyridine (6.0 mmol), Cu(OAc)2 (0.06 mmol), Na2CO3 (0.6 mmol), toluene (10 mL), O2 (balloon), 120−140 °C, 12−30 h. For 2h−2p. Condition B: 1 (0.3 mmol), 2 (1.5 mmol), pyridine (6.0 mmol), Cu(OAc)2 (0.6 mmol), Na2CO3 (0.9 mmol), toluene (10 mL), O2 (balloon), 120−140 °C, 12−30 h.

b

Yields correspond to isolated products.

c

Cu(OAc)2 (0.3 mmol).

d

2g (0.6 mmol), pyridine (1.5 mmol).

e

Yield of product 3h under condition A.