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Comparison of capsaicin-activated currents in ON-bipolar cells of wild-type and TRPM1−/− mice. Patch-clamp recordings were made in the whole-cell mode from ON-bipolar cells in the retinal slice preparation at a holding potential of −60 mV. Capsaicin (100 μM) was applied to the OPL at the time indicated via a “puffer” pipet. These traces are representative of >10 recordings from each genetic background.
