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. 2009 Oct 28;106(45):19023–19028. doi: 10.1073/pnas.0906591106

Fig. 3.

Fig. 3.

Membrane leakiness is minimal in TRPC3 TG myofibers. (A) Immunohistochemistry for δ-sarcoglycan, α-sarcoglycan, and dystrophin in WT and TRPC3 TG quadriceps. Four mice per genotype were analyzed where 400× magnification is shown. (B) Evan's blue dye (EBD) uptake after exercise shown as red fluorescence from WT and TRPC3 TG gastrocnemius and quadriceps. Membranes are stained in green with wheat germ aggluttinin conjugated to FITC where 400× magnification is shown. (C) Quantitation of EBD uptake in muscle from TRPC3 TG and Scgd−/− mice. Four mice were analyzed for each group of mice. EBD myofibers were not observed in WT mice. (D) Quantitation of serum creatine kinase (CK) in WT, TRPC3 TG and Scgd−/− mice at 2 months of age. *, P < 0.05 versus WT; #P < 0.05 versus TRPC3 TG. Number of mice analyzed is shown in the graph. (E) CK serum levels in the indicated groups of mice at 15 months of age. (F) CK serum levels in 2-month-old mice after voluntary wheel running.