Fig. 2.

Systemic deletion of Fbln4 exon 2 leads to complete disruption of elastic tissues. (A) EVG staining of neonatal aorta shows defective development of elastic lamina (Upper), and that of lung shows defective distal airways (Lower) of Fbln4^ΔEx2/ΔEx2 neonate. A small branch of the pulmonary artery (PA) was also affected. (Scale bar, 100 μm.) (B) TEM of neonatal arteries. Fbln4^ΔEx2/ΔEx2 neonates show severely disrupted elastic laminae, similar to those of previously reported Fbln4^null/null mice. (Scale bar, 5 μm.)