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Loss of elasticity in aortae of Fbln4 conditional knockout mice. (A–C) Pressure-diameter relationships of Fbln4 conditional knockout mice. Twelve-week-old mice were used for these analyses. (D) Slopes of pressure-diameter curves. Aortae of Fbln4flox/null Sm+ and Fbln4flox/flox Sm+ mice were significantly stiffer than those of Fbln4flox/flox Sm− mice or Fbln4+/+ Sm+ mice, whereas these two control mice showed no significant difference. Data are represented as means ± SD.
