TABLE 1.
Baseline demographics and presenting characteristics of patients stratified into Global Registry of Acute Coronary Events (GRACE) risk groups
| Characteristic | Overall* (n=7131) |
GRACE risk group (score) |
P (for trend) | ||
|---|---|---|---|---|---|
| Low (≤108) (n=2589) | Intermediate (109–140) (n=2236) | High (≥141) (n=2306) | |||
| Age, years | 68 (57 to 77) | 56 (50 to 63) | 70 (62 to 77) | 78 (71 to 84) | <0.001 |
| Women, % | 34.9 | 28.6 | 36.1 | 40.7 | <0.001 |
| Medical history, % | |||||
| Smoker | 24.0 | 33.2 | 22.2 | 15.2 | <0.001 |
| Dyslipidemia | 56.2 | 57.7 | 59.0 | 51.7 | <0.001 |
| Hypertension | 63.6 | 56.2 | 66.2 | 69.3 | <0.001 |
| Diabetes mellitus | 28.8 | 23.5 | 29.2 | 34.5 | <0.001 |
| Angina | 51.8 | 47.5 | 53.6 | 55.0 | <0.001 |
| Previous myocardial infarction | 36.6 | 30.2 | 36.7 | 43.7 | <0.001 |
| Previous percutaneous coronary intervention | 19.0 | 21.2 | 20.7 | 14.9 | <0.001 |
| Previous coronary artery bypass graft | 14.5 | 11.0 | 16.1 | 17.1 | <0.001 |
| Previous congestive heart failure | 11.6 | 3.0 | 8.6 | 24.0 | <0.001 |
| Previous transient ischemic attack/stroke | 9.8 | 5.2 | 8.9 | 15.8 | <0.001 |
| Previous peripheral vascular disease | 9.8 | 5.3 | 9.6 | 15.2 | <0.001 |
| Presenting characteristics | |||||
| Heart rate, beats/min | 78 (66 to 92) | 74 (64 to 86) | 76 (65 to 89) | 88 (73 to 109) | <0.001 |
| Systolic blood pressure, mmHg | 145 (127 to 164) | 152 (137 to 172) | 145 (128 to 162) | 134 (116 to 154) | <0.001 |
| Killip class, % | |||||
| I | 84.6 | 98.6 | 92.2 | 61.7 | <0.001 |
| II | 10.2 | 1.3 | 6.9 | 23.3 | |
| III/IV | 5.2 | 0.1 | 0.9 | 15.1 | |
| Serum creatinine, μmol/L | 92 (78 to 114) | 85 (74 to 97) | 92 (78 to 110) | 108 (87 to 141) | <0.001 |
| Cardiac arrest, % | 0.5 | 0.0 | 0.2 | 1.4 | <0.001 |
| ST deviation, % | 31.8 | 8.5 | 29.0 | 60.6 | <0.001 |
| Abnormal cardiac biomarker, % | 42.1 | 27.8 | 41.7 | 58.4 | <0.001 |
Data presented as median (interquartile range) unless otherwise indicated.
*
GRACE risk score not calculated for 10% (n=796) of patients due to incomplete data