Skip to main content
. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: J Periodontol. 2009 Aug;80(8):1348–1354. doi: 10.1902/jop.2009.090129

Figure 2.

Figure 2

Developmental defects in Hyp mouse dentin are most severe at 45 dpc and are partially corrected in adulthood. Widths of dentin and predentin for all ages were measured at a site 75μm apical to CEJ (n = 3). For each bar, the combination of black (mineralized dentin) and white (predentin) represents the total dentin width. Means ± SD show decreased total dentin width and an increased proportion of predentin in Hyp versus WT mouse molars. Statistical analysis of total dentin width for all three age groups revealed a significant (P <0.05) decrease in Hyp versus age-matched WT samples, indicating developmental defects in Hyp mouse dentin. A significant (P <0.05) difference in the predentin/dentin ratio in Hyp versus WT was also revealed at 33 and 45 dpc, indicating a considerable lag in dentin mineralization in Hyp mice. However, the large predentin/dentin ratio in the Hyp mouse diminished by 96 dpc (P = 2.2 compared to WT), indicating some recovery in dentin mineralization in adulthood.