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A schematic organization of Shc isoforms. The Shc proteins include three isoforms that are encoded by the same gene. They contain overlapping sequences. Three major tyrosine phosphorylation sites have been identified within the CH1 domain in all Shc isoforms. The unique CH2 domain of p66Shc isoform consists of 110 amino acids and contains a serine phosphorylation site (Ser-36). The PTB domain of p46Shc is deficient of the first 46 amino acids.
