Table 1. Characteristics of 873 Study Participants With Stable Coronary Heart Disease, Stratified by the Presence of Current Depression*.
| Variable | Participants With Depression (n = 195) | Participants Without Depression (n = 678) | P Value |
|---|---|---|---|
| Age, y, mean (SD) | 62 (11) | 68 (10) | <.001 |
| Male | 132 (68) | 580 (86) | <.001 |
| White | 115 (59) | 391 (58) | .76 |
| Married | 64 (33) | 300 (44) | .004 |
| Medical history | |||
| Diabetes mellitus | 57 (29) | 172 (25) | .28 |
| Myocardial infarction | 95 (49) | 381 (56) | .08 |
| Congestive heart failure | 34 (17) | 107 (16) | .60 |
| Hypertension | 139 (71) | 485 (72) | .92 |
| Stroke | 30 (15) | 96 (14) | .67 |
| Revascularization (CABG or PTCA) | 99 (51) | 420 (62) | .006 |
| COPD or asthma | 35 (20) | 103 (16) | .20 |
| Current smoker | 56 (29) | 115 (17) | .002 |
| Regular alcohol use | 56 (29) | 191 (28) | .90 |
| Body mass index, kg/m2, mean (SD) | 29 (5) | 28 (5) | .03 |
| Physically active | 101 (52) | 453 (67) | <.001 |
| Medication use | |||
| β-Blocker | 113 (58) | 406 (60) | .63 |
| Statin | 116 (59) | 453 (67) | .06 |
| Aspirin | 155 (79) | 549 (81) | .64 |
| Renin-angiotensin system inhibitor | 94 (48) | 335 (49) | .77 |
| Antidepressant | |||
| SSRIs | 59 (30) | 31 (5) | <.001 |
| Tricyclic | 14 (7) | 22 (3) | .01 |
| Other | 42 (22) | 30 (4) | <.001 |
| Laboratory test results, mean (SD) | |||
| HDL cholesterol level, mg/dL | 46 (15) | 46 (14) | .85 |
| LDL cholesterol level, mg/dL | 106 (36) | 104 (32) | .37 |
| Glycohemoglobin concentration, % | 6 (1.4) | 6 (1.1) | >.99 |
| Cardiac function | |||
| Resting heart rate, mean (SD) | 67.6 (12.5) | 67.1 (11.6) | .59 |
| Left ventricular ejection fraction ≤55% | 28 (14) | 114 (17) | .41 |
| Wall motion score index, mean (SD) | 1.1 (0.3) | 1.2 (0.4) | .09 |
| Systolic blood pressure, mean (SD) | 133 (22) | 133 (21) | .95 |
| Diastolic blood pressure, mean (SD) | 75 (12) | 74 (11) | .27 |
| Depression score (PHQ27), mean (SD) | 11 (6) | 4 (4) | <.001 |
| Posttraumatic stress disorder | 48 (25) | 31 (5) | <.001 |
| Generalized anxiety disorder | 72 (37) | 18 (3) | <.001 |
Abbreviations: CABG, coronary artery bypass graft; COPD, chronic obstructive pulmonary disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PHQ, Patient Health Questionnaire; PTCA, percutaneous transluminal coronary angioplasty; SSRI, selective serotonin reuptake inhibitor.
To convert to SI factors: HDL and LDL cholesterol to millimoles per liter, multiply by 0.0259.
*
Per the Computerized National Institute of Mental Health Diagnostic Interview Schedule.26 Values are expressed as number (percentage) of patients unless otherwise indicated.