TABLE 4.
Adjusted* Association of Fetuin-A Quartiles With Individual Components of the Metabolic Syndrome
Fetuin-A Quartile Groups |
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1 |
2 |
3 |
4 |
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Reference | OR | 95% CI | OR | 95% CI | OR | 95% CI | P | |
Fasting glucose ≥110 mg/dL or taking diabetes medication | 1 | 1.0 | 0.6–1.7 | 1.0 | 0.6–1.6 | 1.2 | 0.7–2.0 | 0.55 |
SBP ≥130 or DBP ≥85 mm Hg | 1 | 1.0 | 0.6–1.5 | 0.9 | 0.6–1.5 | 1.0 | 0.6–1.7 | 0.99 |
Waist circumference >40 in for men or >35 in for women | 1 | 0.4 | 0.2–0.9 | 0.5 | 0.3–1.2 | 0.6 | 0.3–1.3 | 0.35 |
HDL <40 mg/dL in men or <50 mg/dL in women | 1 | 1.3 | 0.8–2.1 | 1.3 | 0.8–2.1 | 2.0 | 1.2–3.4 | 0.01 |
Triglycerides ≥150 mg/dL | 1 | 3.1 | 1.6–6.0 | 3.2 | 1.7–6.1 | 5.6 | 2.9–10.8 | <0.001 |
LDL ≥130 mg/dL† | 1 | 2.3 | 1.2–4.5 | 2.6 | 1.3–5.2 | 4.6 | 2.4–8.8 | <0.001 |
Non-HDL cholesterol ≥160 mg/dL‡ | 1 | 3.6 | 1.5–8.4 | 3.5 | 1.5–8.2 | 7.8 | 3.4–17.5 | <0.001 |
SBP indicates systolic blood pressure; DBP, diastolic blood pressure.
Adjusted for age, sex, race, tobacco use, alcohol use, creatinine clearance, body mass index, hypertension, albumin, LDL, fibrinogen, and CRP.
LDL was not adjusted in this model because LDL ≥130 mg/dL served as the dependent variable.
LDL was not adjusted in this model because non-HDL is collinear with LDL and non-HDL cholesterol served as the dependent variable.