Table 1.
Clinicodemographic characteristics of 45 childhood leukemia cases
| Pre-B ALL | Pre-T ALL | AML | Other (BL, CML) | Total | |
|---|---|---|---|---|---|
| Sample size, no. | 23 | 6 | 14a | 2 | 45 |
| Mean age, yr (range) | 4.8 (1.3–16.9) | 7.8 (2.6–14.2) | 8.9 (0.3–18.4) | 10.8 (8.2–13.3) | 6.7 (0.3–18.4) |
| Male, no. (%) | 14 (61) | 5 (83) | 9 (64) | 2 (100) | 30 (67) |
| Female, no. (%) | 9 (39) | 1 (17) | 5 (36) | 0 | 15 (33) |
| Sample source, no. | 22 BMA; 1 Pher | 6 BMA | 10 BMA; 2 Pher; 2 PB | 1 BMA; 1 Pher | 39 BMA; 4 Pher; 2 PB |
| Mean blasts, % (range) | 88 (26–100) | 75 (39–88) | 82 (42–100) | 90 (80–100) | 84 (26–100) |
| Dx sample, no. (%) | 21 (91) | 6 (100) | 12 (86) | 2 (100) | 41 (91) |
| Relapse sample, no. (%) | 2 (9) | 0 | 2 (14) | 0 | 4 (9) |
| Mean WBC, no. × 109/L (range) | 36.2 (0.4–252) | 191.4 (13.3–491.4) | 147.9 (0.5–513.6) | 361 (22–700) | 106.1 (0.4–700) |
| CNS 2 or 3, no. (%) | 10 (44) | 2 (33) | NA | NA | 12 (41)b |
| Relapse, no. (%) | 4 (19) | 2 (33) | 4 (40)c | 0 | 10 (26) |
| Survival, no. (%) | 21 (91) | 5 (83) | 7 (54)d | 2 (100) | 35 (81) |
| Hispanic, no. (%) | 5 (22) | 0 | 6 (43) | 1 (50) | 12 (27) |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; BL, Burkitt lymphoma; BMA, bone marrow aspirate; CML, chronic myeloid leukemia; CNS, central nervous system disease; Dx, diagnosis; PB, peripheral blood; Pher, pheresis; WBC, white blood cell count.
a
Includes paired diagnosis and relapse samples from a single patient (counted separately).
b
For only ALL (pre-B + pre-T).
c
Does not include 2 relapsed samples, 1 refractory sample, and 1 early death.
d
Includes paired diagnosis and relapse samples from a single patient (counted as one).