Table 4.
Summary of in vitro data for ester isosteres
| Compounds | R1 | R2 | IC50 (μM) |
|---|---|---|---|
| 12a | H | H | >100 |
| 12b | F | F | >100 |
| 13a | H | H | >100 |
| 13b | F | F | 23.9 |
| 13c | F | H | 38.8 |
| 14 | F | F | 13.8 |
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