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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: FEMS Immunol Med Microbiol. 2009 Mar;55(2):258–270. doi: 10.1111/j.1574-695X.2008.00527.x

Figure 4. Kinetics of genital C. trachomatis serovar K infection in UVEB-immunized or AS01B Adjuvant System-sham-immunized C57BL/6 mice.

Figure 4

Groups of 5 C57BL/6 mice were immunized twice with either UVEB from C. trachomatis serovar E formulated in AS01B Adjuvant System [closed circles] or were AS01B sham-immunized [open circles]. Four weeks after the final immunization, progesterone-treated mice were challenged with an intravaginal dose of 5×105 IFU of C. trachomatis serovar K. Bacterial shedding was quantified by taking swabs on the indicated days and determining the IFU using McCoy cells. Each group was only swabbed once on one of the indicated days post challenge. Bacterial load in the upper genital tract [UGT] was quantified by preparing UGT lysates from sacrificed mice on the indicated days and determining the IFU count using McCoy cells. Data represent means ± SE of IFU from 5 mice. **: P < 0.01, *: P < 0.05 compared with results from AS01B Adjuvant System control mice by unpaired t test. The figure is representative of three separate experiments.