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Chemical structures of IN strand transfer inhibitors used in this study. L-841,411 belongs to the diketo acid family. L-870,810 and L-870,812 are the members of naphthyridine carboxamide family. MK-0518, the first FDA approved inhibitor targeting IN is also shown and belongs to the hydroxypyrimidinone carboxamide group. The diverse class of IN strand transfer inhibitors contain the diketo acid moiety (shown in blue) which interacts with Mg++ in the IN active site.
