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. 2009 Jun 24;29(25):7966–7977. doi: 10.1523/JNEUROSCI.1054-09.2009

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Copyright © 2009 Society for Neuroscience 0270-6474/09/297966-12$15.00/0

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Figure 3. — Loss of CREB function affects the survival rate of newborn dentate granule cells. a, Confocal images of transduced cells in control animals (GFP/RFP) and ACREB-injected animals (ACREB/RFP) at 5, 14, and 28 dpi. The percentage of double-transduced cells (yellow) in ACREB-injected animals is decreased compared with controls at 14 and 28 dpi. RFP-only transduced cells appear in red. DAPI in blue. Scale bar, 25 μm. b, Significant reduction in the survival rate of newborn cells, in which CREB signaling has been ablated starting at 7 dpi (***p < 0.001).