Table 1.
Author | Study design | Follow-up | n | Age group | CD4 increases | Viral load after treatment | Ref. |
---|---|---|---|---|---|---|---|
Viard, (2001) | Cohort | 24–36 months | 1956 (total) | <33 ≥45 |
Time to increase in CD4 by more than 200 cells/mm3: Relative hazard 1.00 0.8 (0.7, 0.9) |
NR | [74] |
Knobel, (2001) | Cohort | 24 months | 671 28 |
≤40 ≥60 |
Mean increase (SD): 228 (145) 196 (100) |
≤50: 51% 67% |
[69] |
Yamashita, (2001) | Cohort | 3–33 months | 397 | <45 ≥45 |
Decreased 3-month CD4 response in those <45 years of age, no effect of age on 6-month CD4 | <400: no difference by age group |
[72] |
Tumbarello, (2003) | Case– control | 116 58 |
20–35 ≥50 |
Increase to CD4 > 200: 79.0 69.0 (p = ns) |
≤50: 72% 79%; p = ns |
[73] | |
Grabar, (2004) | Cohort | Median 32 months | 2614 401 |
<50 ≥50 |
Mean increase in CD4: 17.3 cells/month 14.1 cells/month |
≤500: 70.6% 76.6% |
[68] |
Tumbarello, (2004) | Case– Control | 6 months–6 years | 476 120 |
20–35 >50 |
Increase in CD4 to >200: 79.0 73.0 (p=ns) |
<50: 75% 82% |
[67] |
COHERE, (2008) | Cohort | 2593 1656 1613 |
50–54 55–59 ≥60 |
Time to increase to 100 cells/mm: greatest time in patients >60 years |
Time to viral load <400: less time in patients <60 years > |
[82] | |
Patterson, (2007) | Cohort | 6 months | 63 183 |
<50 ≥50 |
<400: 67% 75% |
[136] | |
Silverberg, (2007) | Cohort | 1 year | 2259 1834 997 |
18–39 40–49 >50 |
Adjusted mean increase in CD4 at 1 year: 142 128 113 |
AHR of <500: 1.0 0.97 (0.89; 1.06) 1.07(0.95; 1.2) |
[138] |
Cuzin, (2007) | Cohort | 6 mos | 540 99 |
<50 ≥50 |
Median increase at 6 months: 100 104 |
NR | [137] |
Bosch, (2007) | ALLRT Cohort | 144 weeks | 1083 | Per 10 years age, ARR 1.05 (1.01–1.09) of viral load <50 at 144 weeks |
[135] |
ALLRT: AIDS longitudinal randomized trials; AHR: Adjusted hazard ratio; ARR: Adjusted rate ratio; NR: Not reported.