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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Annu Rev Biochem. 2009;78:435–475. doi: 10.1146/annurev.biochem.013008.092711

Figure 2.

Figure 2

Cbl protein family in mammals [c-Cbl, Cbl-b, and Cbl-3 (also known as Cbl-c)]. The Cbl proteins contain, from N to C terminus, a TKB domain, a linker region (L), RING finger domain (RF), Pro-rich regions, poly-Pro-Arg motif (PR), and UBA domain. The TKB domain consists of a four-helix bundle (4H), EF hand (EF), and a variant Src homology region 2 (SH2) domain. Cbl-3 lacks the PR motif and UBA domain.