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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Annu Rev Biochem. 2009;78:435–475. doi: 10.1146/annurev.biochem.013008.092711

Figure 5.

Figure 5

A model of ESCRT functioning in EGFR sorting. The UBC-like domain of Vps23, which is a component of ESCRT-I, likely binds to multiubiquitinated EGFR at the membrane of MVBs. ESCRT-II, acting downstream of ESCRT-I, is recruited, and then putatively directs the ESCRT-III complex (which is composed of Vps20, Snf7, Vps2, and Vps24) to the appropriate MVB membrane. ESCRT-III-recruited DUBs remove Ub from cargo proteins, resulting in the invagination of cargo proteins into MVB lumenal vesicles. Vps4 is required for the disassembly and release of the entire MVB sorting machinery, which allows the ESCRT machinery to recycle back into the cytoplasm for further rounds of MVB sorting (170).