Table 2.
Distribution of the CDH1 -347G→GA polymorphism between CRC patients and normal controls
| G-allele (%)1 | GA-allele (%)2 | OR (95% CI)3 | χ2 | P | |
| Controls | 194 (57.9) | 141 (42.1) | |||
| Patients | 153 (52.8) | 137 (47.2) | 1.232 (0.898-1.691) | 1.671 | 0.198 |
| Sex | |||||
| Male | 98 (52.1) | 90 (47.9) | 1.264 (0.882-1.809) | 1.633 | 0.233 |
| Female | 55 (53.9) | 47 (46.1) | 1.176 (0.753-1.836) | 0.508 | 0.495 |
| Age (yr) | |||||
| > 60 | 95 (55.2) | 77 (44.8) | 1.115 (0.770-1.616) | 0.333 | 0.571 |
| ≤ 60 | 58 (49.2) | 60 (50.8) | 1.423 (0.934-2.169) | 2.712 | 0.107 |
| Smoking | |||||
| Yes | 57 (48.7) | 60 (51.3) | 1.448 (0.949-2.210) | 2.967 | 0.105 |
| No | 96 (55.5) | 77 (44.5) | 1.104 (0.762-1.598) | 0.273 | 0.637 |
| Drinking | |||||
| Yes | 66 (51.6) | 62 (48.4) | 1.292 (0.859-1.945) | 1.516 | 0.249 |
| No | 87 (53.7) | 75 (46.3) | 1.186 (0.813-1.730) | 0.786 | 0.386 |
| Location | |||||
| Proximal4 | 63 (45.7) | 75 (54.3) | 1.638 (1.099-2.441) | 5.919 | 0.019 |
| Distal5 | 90 (59.2) | 62 (40.8) | 0.948 (0.642-1.399) | 0.073 | 0.843 |
| Differentiation | |||||
| Well | 116 (56.3) | 90 (43.7) | 1.067 (0.752-1.516) | 0.133 | 0.721 |
| Poorly | 16 (33.3) | 32 (66.7) | 2.752 (1.454-5.209) | 10.240 | 0.002 |
| Other | 21 (58.3) | 15 (41.7) | 0.983 (0.489-1.974) | 0.002 | 1.000 |
| Stage | |||||
| Dukes A/B | 58 (57.4) | 43 (42.6) | 1.020 (0.650-1.600) | 0.007 | 1.000 |
| Dukes C/D | 95 (50.3) | 94 (49.7) | 1.361 (0.951-1.948) | 2.856 | 0.100 |
1
G/G homozygous;
2
GA/GA homozygous; GA/G heterozygous;
3
95% confidence interval;
4
Ascending colon, transverse colon;
5
Descending colon, sigmoid colon, rectum; CDH1: E-cadherin gene.