Figure 7.

Inhibitors mimic substrate binding in serine proteases. (a) Interaction between trypsin-like serine protease (cd00190, 1TB6H, cyan) and antithrombin from serpin superfamily (cd02045, 1TB6I, red). (b) Interaction between serine protease (cd00190, 1XX9B, cyan) and protease inhibitor ecotin (cd00242, 1XX9D, green). The active site of proteases is targeted by different inhibitors; both of them mimic the substrate resulting in inactive proteases. In this case, 67% of the interface residues are shared between two inhibitors as shown in magenta color. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]