Table I.
List of Domain Superfamilies (Containing the Related CDD Domains) with Multibinding Interfaces and Interaction Partners
| Interacting domain partners |
Interacting chains |
||||
|---|---|---|---|---|---|
| Domain superfamily name | Partner1 | Partner2 | PDB1 | PDB2 | Interface overlap ratio |
| 17, Small GTPases | Arfaptin domain, cd00011 | GEF Rho/Rac/ Cdc42-like GTPases, cd00160 | 1I4T:A-D | 1X86:E-F | 58 |
| GEF Ras-like small GTPases, cd00155 | GEF Rho/Rac/ Cdc42-like GTPases, cd00160 | 1NVV:S-R | 1X86:E-F | 50 | |
| Sec7 domain, smart00222 | GEF Rho/Rac/ Cdc42-like GTPases, cd00160 | 1REO:B-A | 1X86:E-F | 53 | |
| RasGEF-N, smart00229 | GRIP domain, pfam01465 | 1XD2:C-A | 1UPT:B-A | 52 | |
| Rab family, cd00154, 17 | Raf-like Ras-binding domain, smart00455 | 1OIV:B-A | 1CIY:B-A | 65 | |
| Rab family, cd00154, 17 | GEF Ras-like small GTPases, cd00155 | 1T91:C-D | 1NVX:S-Q | 60 | |
| 1990, Trypsin-like Serine protease | BPTI/Kunitz serine protease inhibitors, cd00109 | Protease inhibitor ecotin, cd00242 | 1YCO:I-A | 1XX9:D-B | 68 |
| AT_III like, cd02045 | Protease inhibitor ecotin, cd00242 | 1TB6:I-H | 1XX9:D-B | 63 | |
| BPTI/Kunitz serine protease inhibitors, cd00109 | AT_III like, cd02045 | 1YCO:I-A | 1TB6:I-H | 69 | |
| 558, Ubiquitin | RAS small GTPases. smart00173 | Uracil DNA glycosylase, pfam03167 | 1C1Y:A-B | 1WYW:A-B | 56 |
| Peptidase_C12, pfam01088 | Peptidase_C48, pfam02902 | 1XD3:A-B | 1XT9:A-B | 54 | |
| 2129, MHC_I | IG, smart00409 | MHC_I, pfam00129 | 2BNQ:E-A | 1A6Z:C-A | 52 |
| 2263, Transthyretin | Transthyretin, smart00095 | Lipocalin/cytosolic fatty acid-binding protein, pfam00061 | 1ICT:A-F | 1QAB:A-E | 75 |
| 3592, Malic_M | Malic enzyme, N-terminal domain, pfam00390 | Malic enzyme, NAD-binding domain, pfam03949 | 1PJ2:C-B | 1PJ3:C-B | 50 |
| 1936, Immunoglobulin | MHC_I, pfam00129 | MHC_II_alpha, pfam00993 | 1T8O:A-A | 1UVQ:A-B | 64 |
| 2100, EFhand | S-100/ICaBP, calcium-binding domain, pfam01023 | EF hand, pfam00036 | 1M31:B-B | 1XFY:O-O | 88 |
| 1979, Serpin | Heparin cofactor II (HCII) inhibits thrombin, cd02047 | Trypsin-like serine protease, cd00190 | 1LK6:L-I | 1TB6:H-I | 70 |
This is a subset from overall dataset for entries corresponding to human proteins. The first column gives domain family name and its corresponding cluster-id number (See Supporting Information).