Table 2. Bivariate relationships of biologic markers with hemolytic component and hemoglobin oxygen saturation in patients with sickle cell disease [Pearson correlation].

	Hemolytic component (N = 225)		Hemoglobin O2 saturation (N = 233)		Hemoglobin concentration (N = 237)
	R	P	R	P	R	P
Inflammatory markers
Interleukin-6 (pg/ml, natural log)	0.07	0.3	−0.10	0.1	−0.08	0.2
Interleukin-8 (pg/ml, natural log)	0.21	0.001*	−0.20	0.002*	−0.12	0.1
Interferon-γ (pg/ml, natural log)	0.15	0.021	−0.14	0.034	−0.22	0.0006*
Monocyte chemoattractant protein-1 (pg/ml, natural log)	−0.07	0.3	0.01	0.9	−0.05	0.4
Tumor necrosis factor-α (pg/ml, natural log)	0.17	0.012	−0.13	0.049	−0.19	0.004*
Interleukin-10 (pg/ml, natural log)	0.15	0.026	−0.18	0.006	−0.14	0.021
RANTES (ng/ml, natural log)	−0.03	0.7	0.04	0.6	0.17	0.007
Angiogenic markers
Fibroblast growth factor (basic) (pg/ml, sq. root)	0.15	0.022	−0.19	0.004*	−0.24	0.0001*
PDGF- BB (ng/ml, square root)	0.15	0.028	−0.15	0.025	−0.08	0.2
VEGF (pg/ml, natural log)	0.17	0.012	−0.16	0.016	−0.19	0.003*

^*Statistically significant after adjustment for multiple comparisons.