Table 4. Independent predictors of tricuspid regurgitation velocity ≥2.60 m/sec by logistic regression.

	Odds ratio (95% confidence interval)	P
VEGF (pg/ml, natural log)	0.60 (0.42–0.86)	0.005
PDGF-BB (ng/ml, square root)	10.0 (1.77–56.29)	0.009
Interleukin-6 (pg/ml, natural log)	1.60 (1.08–2.38)	0.019
Hemolytic component (relative unit)	1.44 (1.05–1.98)	0.026

186 patients with tricuspid regurgitation velocity <2.6 m/sec; 20 with velocity ≥2.6 m/sec. Variables entered into the analyses hemolytic component, hemoglobin oxygen saturation, chronic transfusion program, hydroxyurea therapy, interleukin-6, interleukin-8, tumor necrosis factor-α, interferon-γ, interleukin-10, RANTES, basic fibroblast growth factor, PDGF-BB and VEGF.