Table 1.
Connections
| Source Layer/Region | Source Cell Type | Targer Layer or Region | Target Cell Type | Receptor | Pmax | Radius | Strength | Mean Delay |
|---|---|---|---|---|---|---|---|---|
| Horizontal intralaminar connections | ||||||||
| L2/3 | Exc | L2/3 | Exc,Inh | AMPA, NMDA | 0.1 | 12 | 0.38 | 1 ± 0.25 |
| L4 | Exc | L4 | Exc,Inh | AMPA,NMDA | 0.05 | 7 | 0.38 | 1 ± 0.25 |
| L5/6 | Exc | L5/6 | Exc,Inh | AMPA,NMDA | 0.1 | 12 | 0.38 | 1 ± 0.25 |
| Vertical interlaminar connections | ||||||||
| L2/3 | Exc | L5/6 | Exc,Inh | AMPA,NMDA | 1 | 2 | 1.88 | 1 ± 0.25 |
| L4 | Exc | L2/3 | Exc,Inh | AMPA,NMDA | 1 | 2 | 1.88 | 1 ± 0.25 |
| L5/6 | Exc | L2/3 | Exc,Inh | AMPA,NMDA | 1 | 2 | 0.47 | 1 ± 0.25 |
| L5/6 | Exc | L4 | Exc,Inh | AMPA,NMDA | 1 | 2 | 0.47 | 1 ± 0.25 |
| Intracortical inhibitory connections | ||||||||
| L2/3 | Inh | L2/3 | Exc,Inh | GABAA | 0.25 | 7 | 0.95 | 0.75 ± 0.1 |
| L4 | Inh | L4 | Exc,Inh | GABAA | 0.25 | 7 | 0.95 | 0.75 ± 0.1 |
| L5/6 | Inh | L5/6 | Exc,Inh | GABAA | 0.25 | 7 | 0.88 | 0.75 ± 0.1 |
| L2/3 | Inh | L2/3,L4,L5/6 | Exc,Inh | GABAA | 1 | 2 | 1.19 | 4 ± 0.25 |
| Forward interareal connections | ||||||||
| L2/3 | Exc | L4 (higher area) | Exc,Inh | AMPA,NMDA | 0.2 | 12 | 0.94 | 12 ± 4.0 |
| 0.00 | ||||||||
| 0.00 | ||||||||
| Feedback interareal connections | ||||||||
| L5/6 | Exc | L2/3,L5/6 (lower area) | Exc,Inh | AMPA,NMDA | 0.15 | 12 | 0.45 | 12 ± 4.0 |
| 0.00 | ||||||||
| 0.00 | ||||||||
| Corticothalamic connections | ||||||||
| L5/6 | Exc | T | Core,Inh | AMPA,NMDA | 0.15 | 12 | 1.69 | 12 ± 2.0 |
| L5/6 | Exc | T | Matrix,Inh | AMPA,NMDA | 1 | 2 | 2.18 | 5 ± 1 |
| L5/6 | Exc | NRT | Inh | AMPA,NMDA | 0.15 | 12 | 4.50 | 12 ± 2.0 |
| Thalamocortical connections | ||||||||
| T | Core | L4 | Exc,Inh | AMPA,NMDA | 0.2 | 4 | 9.00 | 7 ± 0.5 |
| T | Core | L5/6 | Exc,Inh | AMPA,NMDA | 0.2 | 4 | 2.25 | 7 ± 0.5 |
| T | Matrix | L2/3,L5/6 (All areas) | Exc,Inh | AMPA,NMDA | 0.1 | 12 | 1.50 | 7 ± 2.0 |
| Thalamic connections | ||||||||
| T | Exc | NRT | Inh | AMPA,NMDA | 1 | 2 | 3.75 | 2 ± 0.25 |
| T | Inh | T | Exc,Inh | GABAA | 0.3 | 2 | 1.59 | 1 ± 0.25 |
| NRT | Inh | T | Exc,Inh | GABAA | 0.4 | 5 | 0.35 | 1.5 ± 0.25 |
| NRT | Inh | T | Exc,Inh | GABAB | 0.2 | 5 | 0.70 | 1.5 ± 0.25 |
| Noise input | ||||||||
| Cortical noise | Exc | L4 | Exc,Inh | AMPA,NMDA | 0.2 | 12 | 1.00 | 8 ± 4.0 |
| Subcortical noise | Exc | T | Exc,Inh | AMPA,NMDA | 0.2 | 12 | 1.00 | 3 ± 0.25 |
Parameters for the connectivity profiles used to construct the thalamocortical network. Connectivity patterns are specified as follows: source layer or region, source cell type (Exc, excitatory; Inh, inhibitory), layer or region of termination, target cell type, type(s) of synaptic receptor activated by the connection, maximum probability of connection (Pmax), radius of the target to which the projections from a single source cell diverge (expressed in number of topographic elements along vertical and horizontal axis in target map), strength of the connections (expressed in average number of simultaneous postsynaptic potentials per connection) and mean±SD of the conduction delay from the source cell to the target cells. All connections are made to the origin cells same area unless otherwise specified. NMDA, N-methyl-d-aspartate.