Figure 4.

Impact of autologous mesenchymal stem cells therapy on chronic infarct scar remodelling in heart failure. (A) Contiguous short-axis delayed enhanced magnetic resonance imaging images show an example of an untreated animal 12 weeks after injection. The thinned infarct scar and the dilated ventricle can be appreciated. (B) Corresponding images from a high-dose-treated animal. The scar region is thicker and viable myocardium can be appreciated surrounding the scar tissue. (C and D) The effect of mesenchymal stem cell treatment on scar percentage of left ventricular and absolute volume of scar tissue (*P < 0.05 vs. placebo, ^†P < 0.05 week 12 vs. week 24).