Table 3.
Infarct parameters before and 12 weeks after surgery
Week 12 | Week 24 | P-value | ||
---|---|---|---|---|
MI size (% of LV mass) | Placebo | 17.3 ± 1.6 | 18.5 ± 1.2 | 0.57 |
Low-dose MSC | 16.3 ± 1.1 | 12.5 ± 1.0 | 0.06* | |
High-dose MSC | 18.2 ± 0.9 | 14.4 ± 1.0 | 0.018*† | |
Infarct volume (cc) | Placebo | 8.0 ± 0.9 | 8.8 ± 1.1 | 0.59 |
Low-dose MSC | 7.3 ± 0.5 | 6.0 ± 1.2 | 0.37 | |
High-dose MSC | 8.2 ± 0.4 | 6.6 ± 0.5 | 0.03† | |
LV mass (g) | Placebo | 45.9 ± 1.4 | 47.2 ± 3.6 | 0.75 |
Low-dose MSC | 45.1 ± 2.1 | 47.2 ± 4.9 | 0.71 | |
High-dose MSC | 45.3 ± 0.7 | 46.1 ± 1.2 | 0.58 | |
Circumferential extent (% LV circumference) | Placebo | 43.8 ± 1.4 | 45.3 ± 0.8 | 0.39 |
Low-dose MSC | 44.7 ± 2.3 | 36.4 ± 3.3 | 0.11* | |
High-dose MSC | 44.3 ± 2.1 | 31.4 ± 1.3 | 0.001*† | |
Infarct thickness (mm) | Placebo | 4.0 ± 0.1 | 3.6 ± 0.2 | 0.12 |
Low-dose MSC | 3.3 ± 0.1 | 4.9 ± 0.5 | 0.035*† | |
High-dose MSC | 3.9 ± 0.2 | 4.9 ± 0.4 | 0.049*† | |
Remote thickness (mm) | Placebo | 7.1 ± 0.5 | 7.4 ± 0.5 | 0.69 |
Low-dose MSC | 6.9 ± 0.5 | 7.6 ± 0.5 | 0.38 | |
High-dose MSC | 6.6 ± 0.5 | 6.9 ± 0.3 | 0.62 |
All values were calculated based on delayed contrast enhanced magnetic resonance imaging.
MI, myocardial infarction; LV, left ventricular.
*P < 0.05 vs. placebo.
†P < 0.05 week 12 vs. week 24.