Table 3.

Univariate Cox proportional hazards analyses of candidate predictors of cardiovascular mortality in patients with heart failure undergoing cardiac resynchronization therapy

	Univariate
	HR (95% CI)	LR χ2	P-value
Age	1.03 (1.00–1.06)	2.48	0.0914
Female gender	0.24 (0.06–0.99)	3.9	0.0483
Ischaemic aetiology	1.56 (0.72–3.40)	1.28	0.2580
NYHA class	2.79 (1.49–5.23)	10.4	0.0013
Creatinine	1.01 (1.00–1.02)	4.15	0.0417
Log NT pro-BNP	2.79 (1.55–5.26)	12.4	0.0004
Log GDF-15	5.31 (2.31–11.9)	14.6	0.0001
Log combined biomarker index	7.03 (2.91–17.5)	19.1	<0.00001
QRS duration	1.00 (0.99–1.01)	0.25	0.6181
Atrial fibrillation	0.99 (0.47–2.08)	0.00	0.9752
LVEF	0.96 (0.93–0.99)	5.51	0.0189
Medication
Diuretic	0.73 (0.22–2.38)	0.28	0.6146
ACE-I or ARA	1.34 (0.47–3.76)	0.30	0.5848
Beta-blockers	1.77 (0.94–3.35)	3.17	0.0751
Spironolactone	0.98 (0.52–1.83)	0.01	0.9368

LR χ², likelihood ratio chi-squared.