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Comparison of interactions in the IBM-binding cleft. (a) Superposition of cIAP2 BIR3 (green/yellow) with XIAP BIR3 (brown/white). (b) Superposition of NAIP BIR2 (blue/light blue) with XIAP BIR2 (pink) bound to the N-terminus of the processed caspase-3 small domain (sand).