Figure 1.
A ribbon diagram of wild-type FGF-1 (PDB code 1jqz, molecule A) indicating the twofold crystal contact (involving the x, −y, −z symmetry operator) adjacent to position Glu81. Also shown are the side chains of Glu82 and Lys101 (the positions subjected to mutation to improve this crystal contact); symmetry-related positions are indicated with asterisks. Green positions indicate the molecular interface with the FGF receptor and red positions indicate the molecular interface with heparin (Stauber et al., 2000 ▶; Schlessinger et al., 2000 ▶). The orientation of the cell edges are indicated (the view is down the a cell edge).
