Table 1. Data-collection statistics for TcDHFR-TS crystals.

Values in parentheses are for the highest resolution shell.

	TcDHFR-TS–C-448–NDP–dUMP	TcDHFR-TS–CYC–NDP	TcDHFR-TS–CYC	TcDHFR-TS–Q-8–NDP
Wavelength (Å)	1.1	1.54	0.9	1.54
Space group	C2221	P21	P21	P21
Molecules per ASU	2	4	4	4
Unit-cell parameters
a (Å)	93.88	81.39	81.43	81.54
b (Å)	136.90	166.04	165.79	165.94
c (Å)	167.82	84.84	84.76	84.72
β (°)	90	113.31	113.39	113.41
Resolution (Å)	50–2.37 (2.45–2.37)	50–2.60 (2.69–2.60)	30–2.1 (2.18–2.10)	50–2.80 (2.90–2.80)
No. of measured reflections	113143	144301	308944	94398
No. of unique reflections	38355	56446	104144	45782
Redundancy	2.8	2.5	2.8	2.1
Completeness (%)	91 (85)	94 (83)	91 (80)	95 (85)
〈I/σ(I)〉	12.8 (8.3)	10.6 (2.6)	10.0 (1.9)	8.7 (1.6)
Rmerge† (%)	6.1 (12)	7.3 (29.6)	10.3 (40.8)	9.7 (39.7)
Wilson B factor (Å2)	35	45	31	48

^† R _merge = , where I _i(hkl) is the intensity of the ith measurement of an equivalent reflection with indices hkl and 〈I(hkl)〉 is the mean intensity of I _i(hkl) for all i measurements.