Table 4.

Variables Included in Pretreatment Prediction Model for Clinical Failure Based on Systems Pathology Platform (in Order of Weighted Significance)

Clinical/Pathologic Variables

Preoperative PSA

Dominant Gleason grade

Biopsy Gleason score

Biomarker Variable

Combined androgen receptor dynamic range at dominant Gleason grade ≦ 3, total Ki-67 at dominant Gleason grade > 3

Advanced Imaging Variables

Combined mean distance between epithelial tumor cells at dominant Gleason grade ≦ 3, actual grade at dominant Gleason grade > 3

Area of isolated (non-lumen associated) tumor epithelial cells relative to total tumor area

PSA, prostate-specific antigen.

Data from Donovan et al.³⁴