Table 5.

Variables Included in Pretreatment Prediction Model for Favorable Pathology Based on Systems Pathology Platform (in Order of Weighted Significance)

Clinical/Pathologic Variables

Preoperative PSA

Biopsy Gleason score

Advanced Imaging Variables

Area of isolated (non-lumen associated) tumor epithelial nuclei relative to total tumor area

Area of epithelial nuclei with differential distance from gland lumens relative to total tumor area

Biomarker Variable

Combined androgen receptor dynamic range at dominant Gleason grade ≦ 3, total Ki-67 at dominant Gleason grade > 3

PSA, prostate-specific antigen.

Data from Donovan et al.³⁴