FIG. 1.

Modulation of AFB-DNA adduct formation by phytochemicals in cultured human primary hepatocytes. Hepatocytes were treated with two doses of each phytochemical for 48 h and subsequently coincubated with 0.4μM ³H-AFB and phytochemical. Control represents non-modulated AFB-DNA adduct level and was treated with solvent instead of phytochemical. AFB-DNA adduct levels are expressed as percentages over non-modulated control and represent means and SEs from six independent experiments. The control AFB-DNA adduct level averaged 5.4 adducts per 10⁷ nucleotides (range 1.7–9.9 adducts per 10⁷ nucleotides). *Denotes 0.01 < p < 0.05, **denotes p < 0.01.