FIG. 7.

Micrographs of the urethra, testis, and tail of the epididymis in adult rats treated neonatally with oil (control) or EE at a dose of 1 μg or 10 μg/rat on every other day from postnatal days 1 to 11. Urethra: Compared to controls, note leukocytic infiltration, mainly lymphocytes (arrows), in the urethral epithelium and the surrounding corpus spongiosus (CS) in 1/5 animals of the 10-μg group. Testis: Note that spermatogenesis was normal and similar in controls and all treated groups, except 2/5 animals in the 10-μg group where Sertoli cell–only seminiferous tubules (*) were prevalent. Tail of the epididymis: Note leukocytic infiltration, mainly lymphocytes (arrows), that was observed in 1/5 animals in the 1-μg group and 3/5 animals in the 10-μg group; H&E staining.