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Mn differentially modulates striatal DA levels in developing and adult mice. Juvenile mice (days 20–34) exposed to 10 and 30 mg/kg MnCl2 had a significant increase in striatal DA (A) but no significant change was detected in mice exposed only as adults (weeks 12–20) (B). DA levels were decreased in the striatum of adult mice preexposed to MnCl2 as juveniles (days 20–34 and weeks 12–20) (C) (*p < 0.05).
