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Mn differentially modulates striatal DOPAC levels in developing and adult mice. Juvenile (days 20–34) (A) and adult (weeks 12–20) (B) mice exposed to 30 mg/kg MnCl2 had significant decreases in striatal DOPAC levels. DOPAC levels were also decreased at both 10 and 30 mg/kg Mn in adult mice preexposed to MnCl2 as juveniles (days 20–34 and weeks 12–20) (C). Differing letters denote statistical significance (p < 0.05).
