TABLE 3.

Copper in Brain and Serum of Juvenile and Adult Mice Exposed to Manganese (parts per million)

Time of exposure	Treatment, mg/kg (MnCl2·4H2O)	Striatum	SN	Cortex	Hypothalamus	Serum
Juvenile	0	1.8 ± 0.07	2.0 ± 0.13	4.07 ± 0.68	4.1 ± 0.75	0.24 ± 0.004
	10	1.9 ± 0.16	3.8 ± 0.93a	2.8 ± 0.50	5.5 ± 0.54	0.22 ± 0.002
	30	2.5 ± 0.06	9.9b	7.7 ± 1.23	3.04 ± 0.81	0.23 ± 0.003
Adults	0	8.1 ± 0.91	4.1 ± 1.85	2.9 ± 0.82	5.5 ± 2.73	0.32 ± 0.009
	10	10.1 ± 0.52	8.4 ± 0.46	13.5 ± 4.03	8.9 ± 2.4	0.34 ± 0.028
	30	9.5 ± 0.58	10.2 ± 1.58	13.2 ± 1.27a	11.9 ± 1.47	0.34 ± 0.008
Juvenile and adult	0	8.7 ± 0.72	8.0 ± 0.14	5.6 ± 0.52	7.6 ± 0.73	0.21 ± 0.015
	10	9.6 ± 0.42	9.7 ± 0.52	7.08 ± 1.18	8.3 ± 0.52	0.26 ± 0.007
	30	10.1 ± 0.28	7.6 ± 1.03	5.86 ± 0.76	5.18 ± 0.35	0.25 ± 0.01

Note. Data shown are means ± SEM (n ≥ 3).

^aSignificance compared to controls within a specific brain region per exposure group is denoted by (p < 0.05).

^bn equals 1 for this sample.