TABLE 2.

Pathological Scoring of Microgliosis in Specific Brain Regions of Mice Exposed to Mn: IBA-1^a

Time of exposure	Treatment (MnCl2 in mg/kg)	Gp	St	SNpr
Juvenile	0	0.33 ± 0.09	0.0 ± 0.0	0.67 ± 0.06
	10	1.5 ± 0.06*	1.3 ± 0.04*	1.6 ± 0.06*
	30	1.4 ± 0.08*	1.2 ± 0.06*	1.3 ± 0.13*
Adult	0	0.8 ± 0.13	0.8 ± 0.16	0.86 ± 0.05
	10	1.5 ± 0.17	1.7 ± 0.08	0.6 ± 0.08
	30	2.8 ± 0.10*	2.7 ± 0.1*	2.2 ± 0.07*
Juvenile + adult	0	0.8 ± 0.08	0.5 ± 0.05	1.1 ± 0.03
	10	0.6 ± 0.11	0.5 ± 0.11	1.1 ± 0.03
	30	0.5 ± 0.30	1.10 ± 0.09	1.7 ± 0.09

Note. Data shown are mean ± SEM (n ≥ 3). Significance compared with controls within a specific brain region (GP, ST, or SNpr) per exposure group is denoted by “*”(p < 0.05).

^aNo microglia = 0; activated microglia = 3.