FIG. 2.

Dose-response curves of H₂O₂ production in isolated rat brain mitochondria stimulated by redox cycling bipyridyl herbicides. Mitochondria were stimulated with (A) malate + glutamate or (B) succinate + rotenone and treated with PQ (solid line), DQ (dashed line), or BV (dotted line) at increasing concentrations. EC₅₀ values were calculated to determine the potency of each compound in terms of H₂O₂ production (see text).